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人才隊伍

宋昕陽
研究員，研究組長，博士生導師
E-mail: xinyang.song@sibcb.ac.cn
實驗室主頁:

個人簡介：

　　2007年畢業于中國藥科大學生命科學與技術學院，獲理學學士學位。2014年畢業于中科院上海生命科學研究院健康科學研究所(現上海營養與健康研究所)，獲理學博士學位。2016至2021年于美國哈佛醫學院免疫學系從事博士后研究。2021年6月起任中科院分子細胞科學卓越創新中心(生物化學與細胞生物學研究所)研究員，研究組長，博士生導師。

社會任職：

研究方向：

黏膜穩態與疾病

研究工作：

　　機體的黏膜表面存在大量與宿主免疫系統相互作用的共生微生物。這些微生物包括細菌，真菌，病毒以及少量原生生物，其基因組合集被稱為微生物組。作為人體的“第二基因組”，其所編碼的代謝通路可將來源于機體和食物的天然產物轉化為包括萜類，脂類，寡糖，氨基酸以及脂肪酸衍生物在內的多種小分子代謝產物。此外，人體微生物組的代謝通路亦可對異生化合物如藥物分子進行多種修飾。近年來，雖然高通量測序技術的發展使得鑒定或預測大量微生物來源的小分子及其生物合成相關基因成為可能，但我們仍不清楚這些小分子代謝產物所介導的信號網絡調控宿主黏膜免疫系統發育與功能，進而影響機體生理與病理的內在機理。由此，本實驗室的研究重點在于系統闡明各類微生物來源的小分子代謝產物調控宿主黏膜免疫穩態以及疾病易感性的分子機理。依據前期的分子機理研究，我們亦致力于開發基于共生微生物基因組編輯技術的新型診斷與治療途徑。
　　我們將利用無菌小鼠模型和小鼠遺傳修飾或疾病模型，并結合免疫學，微生物學(特別是細菌遺傳學)，分子生物學，基因組學，轉錄組學以及代謝組學等多學科技術手段開展以下三個方向的科學研究：
　　1. 黏膜免疫細胞發育，成熟的分子機理及其功能；
　　2. 共生微生物對于黏膜免疫細胞調控的分子機理；
　　3. 新型共生微生物基因組編輯工具的開發與應用。

承擔科研項目情況：

代表論著：

1. Zhang H, Xie Y, Cao F, Song X*. 2024. Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions. Gut Microbes 16 (1), 2382336. (* Correspondence author, Invited review)
2. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X*, Zhu S*, Pan W*. 2024. Enterococcus-derived tyramine hijacks a2A-adrenergic receptor in intestinal stem cells to exacerbate colitis. Cell Host Microbe 32 (6), 950-963. e8. (* Co-correspondence author)
3. Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. 2024. Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8⁺ T cell effector functions. Immunity 57 (4), 876–889. e11.
4. Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed JD, Ringel A, Barends J, Wu C, Balskus EP, Thiagarajah JR, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper S. 2024. Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol 18 (2):101350.
5. Xie Y, Zhang H, Song X*. 2024. AEP promotes aberrant RNA splicing through DDX3X cleavage in solid tumors. J Clin Invest 134 (3):e177609. (* Correspondence author, Invited commentary)
6. Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL. 2024. Gut complement induced by the microbiota combats pathogens and spares commensals. Cell 187 (4), 897–913. e18.
7. Peng H, Qiu J, Zhou Q, Zhang Y, Chen Q, Yin Y, Su W, Yu S, Wang Y, Cai Y, Gu M, Zhang H, Sun Q, Hu G, Wu Y, Liu J, Chen S*, Zhu Z*, Song X*, Zhou J*. 2023. Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis. Immunity?56 (12), 2773–2789. e8. (* Co-correspondence author)
8. Song X^?*, Zhang H^?, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W, Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF & Kasper DL*. 2023. Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature 619 (7971), 837-843. (? Co-first author, * Co-correspondence author)
9. Yang T, Wang G, Zhang M, Hu X, Li Q, Yun F, Xing Y, Song X, Zhang H, Hu G, Qian Y. 2023. Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis. Cell Rep 42 (11):113377.
10. Song X*, Sun X*, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. 2020. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. Nature?577 (7790), 410-415. (* Co-first author)
11. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh SF, Mekalanos J, Kasper DL. 2020. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature 577 (7791), 543–548.
12. Yang D, Xing Y, Song X, Qian Y. 2020. The impact of lung microbiota dysbiosis on inflammation. Immunology 159 (2), 156-166.
13. Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y. 2019. Dysregulated lung commensal bacteria drive Interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles. Immunity 50 (3), 692-706. e7.
14. Zhang Y, Xin D, Wang Z, Song X, Sun Y, Zou Q, Yue J, Zhang C, Zhang J, Liu Z, Zhang X, Zhao T, Su B, Chin Y. 2019. STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J 38 (6):e99595.
15. Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y. 2018. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med 215 (11), 2850-2867.
16. Cao M, Chen F, Xie N, Cao M, Chen P, Lou Q, Zhao Y, He C, Zhang S, Song X, Sun Y, Zhu W, Mou L, Luan S & Gao H. 2018. c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and-independent activities. Cell Death Dis 9 (12):1140.
17. Shao X, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. 2017. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep 7 (1), 7024. (* Co-correspondence author)
18. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y. 2017. Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nature Commun 8 (1), 15402.
19. Song X*, He X*, Li X, Qian Y. 2016. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 13 (4), 418-431. (Invited review, * Co-first author)
20. Song X*, Dai D*, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. 2015. Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage. Immunity?43 (3), 488–501. (* Co-first author)
21. Song X*. 2015. Intestinal microbiota mining: a Th17/Treg cell perspective. Eur J Bio Med Res 1 (4), 28-35. (Invited review, * Correspondence author)
22. Song X*, Gao H*, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40 (1), 140-152. (* Co-first author)
23. Song X, Gao H, Qian Y. 2014. Chapter V: Th17 differentiation and their pro-inflammation function. Springer Press. Adv Exp Med Biol 841:99-151. (Invited book chapter)
24. Song X, Qian Y. 2013. Peli1 sets the CNS on fire. Nat Med 19 (5):536-538. (Invited preview)
25. Song X, Qian Y. 2013. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal 25 (12):2335-2347. (Invited review)
26. Song X, Qian Y. 2013. The activation and regulation of IL-17 receptor-mediated signaling. Cytokine 62 (2):175-182. (Invited review)
27. Zhu S, Pan W, Song X, Liu Y, Tang Y, Wang H, Liu W, Shi Y, He D, J.B Harley, Shen N, Qian Y. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 18 (7):1077-1086.
28. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 12 (12):1151-1158.
29. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 207 (12):2647-2662.

個人簡介：

社會任職：

研究方向：

研究工作：

承擔科研項目情況：

代表論著：

獲獎及榮譽：

研究組成員：